Congratulations to all the authors on this new advance!
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Congratulations to NSF Fellow Lisa Tostanoski whose ACS Nano paper is now available online. The work describes self-assembly of immune signals to create the first polyelectrolyte multilayers designed to promote immunological tolerance. The findings demonstrate a unique approach for creating tolerance by targeting inflammatory pathways (toll-like receptors) that have recently been discovered to be over-active during autoimmune diseases such as multiple sclerosis, type 1 diabetes, and lupus. The ultimate goal is to enable treatments for autoimmune diseases that are more effective and specific. In this first study, we demonstrate that immune-polyelectrolyte multilayers (iPEMs) promote tolerance in cells from animals, rodent models of multiple sclerosis, and in samples from human multiple sclerosis patients. The project is a collaboration with Dr. Walter Royal at the Baltimore VA and is freely available through Open Access.
Congratulations to all the authors on this new advance! Comments are closed.
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January 2021
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