Congratulations to NSF Fellow Lisa Tostanoski whose ACS Nano paper is now available online. The work describes self-assembly of immune signals to create the first polyelectrolyte multilayers designed to promote immunological tolerance. The findings demonstrate a unique approach for creating tolerance by targeting inflammatory pathways (toll-like receptors) that have recently been discovered to be over-active during autoimmune diseases such as multiple sclerosis, type 1 diabetes, and lupus. The ultimate goal is to enable treatments for autoimmune diseases that are more effective and specific. In this first study, we demonstrate that immune-polyelectrolyte multilayers (iPEMs) promote tolerance in cells from animals, rodent models of multiple sclerosis, and in samples from human multiple sclerosis patients. The project is a collaboration with Dr. Walter Royal at the Baltimore VA and is freely available through Open Access.
Congratulations to all the authors on this new advance!
Congratulations to all the authors on this new advance!