• Associate Professor, Fischell Dept. of Bioengineering, University of Maryland • Associate Chair for Research, Fischell Dept. of Bioengineering, University of Maryland • Research Microbiologist, United States Department of Veterans Affairs, BLR&D Service • Damon Runyon-Rachleff Innovator • Affiliate faculty, Immunology & Microbiology, University of Maryland Medical School • Full Member, Tumor Immunology Program, Marlene & Stewart Greenebaum Cancer Center
Christopher M. Jewell is an Associate Professor in the Fischell Department of Bioengineering at the University of Maryland and a Damon Runyon-Rachleff Innovator. He is also an Associate Scientific Advisor for Science Translational Medicine. Dr. Jewell graduated from Lehigh University with high honors in 2003 with a B.S. in Chemical Engineering and a B.S. in Molecular Biology. He attended graduate school at the University of Wisconsin – Madison, completing his PhD in Chemical Engineering with Professor David Lynn in 2008. Chris then joined the Boston Consulting Group in New York City as a consultant in the Healthcare practice, where his work focused on R&D strategy development for global pharmaceutical and biotechnology clients. In 2009, Dr. Jewell accepted a postdoctoral fellowship from the Ragon Institute to begin vaccine research at MIT with Professor Darrell Irvine in the departments of Materials Science and Biological Engineering. Dr. Jewell held a concurrent appointment as a Visiting Scientist in the Division of Vaccine Research at Harvard. In August 2012, Chris established his lab at the University of Maryland. His research focuses on understanding the interactions between synthetic materials and lymph nodes, and exploiting these interactions for therapeutic vaccination.
Dr. Jewell has authored more than 70 papers and patent filings, including papers in ACS Nano, Cell Reports, PNAS, and Nature. These efforts have been recognized by awards for research and education, including the NSF CAREER Award, the Damon Runyon-Rachleff Innovation Award, the Alliance for Cancer Gene Therapy Young Investigator Award, the Melanoma Research Alliance Young Investigator Award, the University of Maryland Research and Scholar Award, and the University of Maryland's 2017 Graduate Faculty Mentor of the Year. Dr. Jewell also leads the lab's outreach efforts, working with more than 500 area high school students to promote STEM research exposure, building community awareness about STEM opportunities in the cancer field, and fundraising for local and national charities. Chris was previously the recipient of a Society for Biomaterials STAR Award, an American Association of Immunologists Trainee Award, and the Controlled Release Society T. Nagai Postdoctoral Achievement Award. In 2012, Dr. Jewell appeared in USA Today representing the Chemical Engineering discipline as a “New Face of Engineering” during National Engineers Week. Chris was also selected in 2013 as the state of Maryland’s Outstanding Young Engineer by the Maryland Academy of Science, the state’s highest professional honor awarded to an engineer under 36.
Dr. Xiangbin Zeng is the Lab Manager and technician for the Jewell Research Lab in the Fischell Department of Bioengineering at the University of Maryland. He currently holds the rank of Senior Faculty Specialist. Dr. Zeng received his Bachelors degree in preventive medicine from Shanghai Medical University in China in 1997, and his Ph.D. in Toxicology from Fudan University in China in 2002. Dr. Zeng then conducted postdoctoral research at Tulane University before joining the Department of Radiation Oncology at Emory University Medical Center as a Research Association in 2006. Dr. Zeng’s cancer research at Emory focused on the role of centrosome amplification during tumorgenesis in human mammary glands. Xiangbin also served as a volunteer at the NIH for 1 year investigating the role of adaptive immune reactions during drug-induced liver injury in mice. Dr. Zeng’s past work has resulted in more than a dozen peer-reviewed publications in the fields of immunology and cancer. In addition to coordinating Jewell lab operations, his current position utilizes his expertise in molecular cell biology and immunology to help other lab members to push research projects forward. In his free time, Xiangbin is a big tennis fan and enjoys spending time with his two kids.
Dr. Geoffrey Lynn, Ph.D.
Dr. Geoffrey Lynn is a visiting scientist in the Jewell Lab and co-founder of the Baltimore, MD based start-up, Avidea Technologies. His research interests center around the development of polymer-based drug delivery systems for a variety of medicinal applications ranging from cancer immunotherapy and infectious disease prophylaxis to immune-suppression. Geoffrey has a B.S. in chemistry from Elon University and a D.Phil. in Biomedical Engineering from Oxford University.
Dr. Qin Zeng is currently a postdoctoral scientist in the Jewell Research Lab in the Fischell Department of Bioengineering at the University of Maryland. Dr. Zeng received her B.S degree in Pharmacy from Hubei University of traditional medicine in 2009 and joined the Key Laboratory of Drug-Targeting and Drug Delivery System in Sichuan University. She completed a Master degree in 2012 and Ph.D degree in Pharmaceutics in 2015. Her master research focused on melanoma gene therapy using adenovirus complexed with a PEG derived polymer. During her doctoral studies, Qin constructed micelles-based cancer vaccines for melanoma immunotherapy. She has published three first author papers in top drug delivery journals such as the Journal of Controlled Release, and earned the National Scholarship for Outstanding Graduate Student. In the Jewell Lab, Dr. Zeng is continuing in the cancer immunotherapy field with an emphasis on controlling CD8+ T cell phenotype and deciphering the interactions or biomaterial-based cancer vaccines with the local lymph node microenvironment.
Michelle graduated from Brown University in 2013 with a B.S. in Chemical and Biochemical Engineering. She went on to receive her M.S. in Biomedical Engineering from Brown in 2014. While at Brown, Michelle worked under the direction of Dr. Anubhav Tripathi to study the bioremediation of oil spills utilizing hydrocarbon-degrading marine bacterium. Her work on this subject led to two first author publications. In the Jewell lab, Michelle's research focuses on using self-assembly to understand the trafficking and processing of immune signals. Michelle is an NIH doctoral fellow on the Host Pathogen Interactions T32. In her free time, Michelle enjoys running and traveling.
Haleigh graduated from Indiana University in 2016 with a B.S. in Biotechnology and a B.A. in Computer Science. At Indiana University, she worked for Dr. Robert Vaughan developing an assay to use mass spectroscopy to determine peptide and protein structures. For this work, she earned first place in biotechnology in the Hutton Honor Research Symposium. Concurrently, she worked for Dr. Predrag Radivojac developing a genomic pathogenicity predictor using annotated Actinobacteria genomes. In the fall of 2016, she entered University of Maryland’s Molecular and Cellular Biology PhD program. Haleigh is an NIH doctoral fellow on the Molecular and Cellular Biology T32 and is studying immune tolerance in the Jewell lab. In her down time, she enjoys embroidery and cross stitch.
Eugene Froimchuk graduated from the University of Maryland in 2016 with a B.S. in Biochemistry & Biological Sciences (specializing in Physiology & Neurobiology). After graduating, he worked in Dr. Kai Ge's lab at the National Institute of Health researching epigenetic regulation of adipogenesis as an NIH IRTA fellow. While at the University of Maryland, Eugene worked in Dr. Patrick Kanold's lab to investigate the physiological causes of tinnitus. He also worked in Dr. Nevil Singh's lab at the University of Maryland School of Medicine as part of the UM Scholar's program during the summer of 2015. While working in Dr. Singh's lab, Eugene studied the species-specific function of IL-2 protein. After working in Dr. Singh's lab, he discovered a newfound interest for immunology and joined the Jewell Lab as a Clark School Graduate Fellow. Outside of lab, Eugene enjoys hiking, basketball, reading, and listening to music and podcasts.
Joshua graduated in August 2012 with a B.S. in Bioengineering from the University of Maryland. As an undergraduate, Josh gained experience in medical device design as his capstone group achieved second place overall in the 2011-2012 UMD Bioengineering Capstone Design Competition. Josh is currently completing a Masters of Science in Bioengineering, working to develop a polymeric delivery system to help control neurodegeneration. He is continuing in his research as a PhRMA Foundation Doctoral Fellow and was previously the recipient of a Pediatric Oncology Student Training award from Alex's Lemonade Stand Foundation. Josh has also volunteered at Civista Medical Center in La Plata Maryland, assisting patients with physical therapy. In his free time he enjoys reading and spending time with his dog, Soto.
Emily graduated from Tufts University in May 2015 with a B.S. in Biomedical Engineering. She is a member of the engineering honors society Tau Beta Pi, and graduated Magna Cum Laude. While at Tufts, Emily worked in Dr. David Kaplan’s Laboratory using silk fibroin as a biomaterial scaffold for cornea tissue engineering applications. For her work on this project, she earned the Tufts BME Senior Capstone of the Year Award and the Tufts Benjamin G. Brown Scholarship for research. In joining the Jewell Research Lab, she hopes to continue studying the use of biomaterials, but with a focus on using materials to regulate immune tolerance. Outside of research, Emily enjoys running, and ran her first half marathon in 2015. She is a strong supporter of Boston sports.
Krystina graduated from Syracuse University with a Bachelor’s in Bioengineering in May 2013. She was a member of the Renée Crown University Honors Program and graduated cum laude. Krystina worked at the Syracuse Biomaterials Institute as an undergraduate researcher beginning in her sophomore year. Under the direction of Dr. Rebecca Bader, she synthesized hyaluronate–coated polysaccharide nanoparticles for active targeting to inflamed tissue in rheumatoid arthritis. Krystina current projects in the Jewell lab focus on exploiting self-assembling materials to regulate immune function. She is currently a Department of Defense SMART Fellows and will launch a independent research career at Aberdeen Proving Ground after completing her PhD. Krystina has received several other awards, including the University of Maryland's Summer Research Fellowship. Krystina is a devoted Boston Red Sox and Buffalo Bills fan and also enjoys traveling.
Shannon graduated from the University of Pennsylvania in May 2012 with a B.S. in Materials Science. After graduation, Shannon worked in the lab of Dr. Andrew Rhim, performing clinical tests on microfluidic chips to screen for breast, ovarian, and pancreatic cancers. Shannon then joined the lab of Dr. Rebecca Wells, where she worked as a technician studying the role of mechanical factors on liver fibrosis and the mechanism behind biliary atresia. In Fall 2016 Shannon enrolled as a doctoral student at the University of Maryland to focus on the application of biomaterials and bioengineering to immunology. She is an NIH NCI Doctoral Fellow. Outside of her research in the Jewell Lab, Shannon is a competitive ultimate Frisbee player for a Nationals qualifying team.
Lampouguin (Douti) graduated from the University of Maryland in 2015 with a B.S. in Bioengineering. He is a member of the engineering honors society Phi Theta Kappa and is currently a National Science Foundation Bridge-to-the-Doctorate Graduate Fellow. Lampouguin has also received a University of Maryland Fellowship to support his graduate studies. Lampouguin’s doctoral research is in the Malaria area, supervised by Dr. Carolina Barillas-Mury at the NIH Malaria Branch, and co-advised by Dr. Jewell. Lampouguin is also working to integrate biomaterials into improved malaria vaccines. Outside of research, Lampouguin enjoys playing soccer and tennis.
High School Research Interns
Allie Amerman is a junior at Wheaton High School planning to graduate in 2019. She is part of her school's PLTW engineering track and plans to major in Chemical Engineering or Materials Science. Allie joined Dr. Jewell's lab in the fall of 2017 to work with Graduate Fellow Shannon Tsai. Her project focuses on using self-assembled materials to control T cell function to fight cancer. During her free time, Allie codes video games and plays guitar and piano.
Lab Alumni: Postdoctoral Scientists
Dr. Ashlee Tipton, Ph.D. (April 2014 - May 2015)
Dr. Ashlee Tipton joined the lab in 2014 as a postdoctoral research associate. Dr. Tipton received her B.S. in Biological Sciences from University of Maryland, College Park in 2008. She completed her graduate training at Georgia Regents University, earning a Ph.D in Biomedical Sciences with a major in Vascular Biology with Dr. Jennifer C. Sullivan in 2014. Dr. Tipton’s graduate work focused on elucidating the mechanism by which T cells contribute to hypertension in spontaneously hypertensive rats (SHR) and tested the hypothesis that there is a sex difference in the contribution of T cells to the maintenance of hypertension in SHR. Her research in the Jewell lab included engineering biomaterials for harnessing immune function during cardiovascular disease. She received an American Heart Association Fellowship for her proposal in this area (declined). Ashlee completed her time in the lab in 2015.
Next position: Program Officer, NIH, National Center for Complementary & Integrative Health
Dr. Yu-Chieh Chiu, Ph.D. (July 2013 - August 2016)
Dr. Yu-Chieh Chiu was an NIH Postdoctoral Fellow in the Jewell Research Lab. Dr. Chiu received his B.S. in Chemical Engineering from National Taiwan University of Science and Technology in 2003. He completed his graduate training at the Illinois Institute of Technology, earning an M.S. in Chemical Engineering with Dr. Victor Perez-Luna in 2007 and a Ph.D. in Biomedical Engineering with Dr. Eric Brey in 2011. After graduate school, Yu-Chieh accepted a postdoctoral position at Rice University with Dr. Antonios Mikos and was co-mentored by Dr. Cindy Farach-Carson in the department of Bioengineering. Dr. Chiu’s research focused on controlled delivery of growth factors from functionalized biodegradable scaffolds for bone and cartilage engineering. His work in the lab focused on self assembly of immune signals to to study and improve the generation of CD8+ T cell response during cancer vaccination. Yu-Chieh completed work in the lab in 2016.
Next position: Scientist II, U.S. Food and Drug Adminstration, Office of Vaccines Research and Review
Dr. Peipei Zhang, Ph.D. (August 2014 - June 2017)
Dr. Peipei Zhang was a postdoctoral associate in the Jewell Research Lab. Dr. Zhang received his B.S. in Bioengineering in Northwest A & F University in China in 2006. He continued his graduate study in Chemical Engineering at South China University of Technology from 2006-2008. He completed his graduate training at the Florida State University, earning his Ph.D. in Biomedical/Chemical Engineering with Dr. Jingjiao Guan in 2013. After graduate school, Peipei worked as a postdoctoral researcher at Worcester Polytechnic Institute with Dr. Ming Su. Dr. Zhang’s research focused on micro/nanofabrication of particulate device for biomedical applications, e.g. drug delivery and cell tracking. His research interests in the Jewell lab included using self-assembling materials to control immune polarization and using microfluidic devices to image cytoskeletal dynamics in free-floating tumor cells. Peipei enjoys reading and traveling, and likes to visit museums. Dr. Zhang completed his time in the lab in 2017.
Lab Alumni: Graduate Students
Dr. James I. Andorko IV, Ph.D. (January 2013 - June 2017)
Jim was an American Association of Pharmaceutical Scientists (AAPS) Graduate Fellow, a University of Maryland Graduate Dean's Dissertation Fellow, and previously received an NIH doctoral fellowship. Prior to joining the University of Maryland, he completed a combined degree program at Drexel University in Philadelphia, graduating magna cum laude in 2012 with a Bachelor’s and Master’s in Biomedical Engineering. Jim's master’s thesis focused on stealth drug delivery vehicles meant to avoid immune detection. During his time at Drexel, he worked in Dr. Margaret Wheatley’s Microencapsulation Laboratory at Drexel, and completed internships in Merck’s RNAi Therapeutics Division and at Synthes in the Biomaterials Division. Jim's doctoral work focused on how biomaterials used in vaccines impact immune signaling pathways. In particular, he studied the relationship between physical and chemical properties of biomaterial vaccine carriers and how the properties of these materials impact the lymph node environment. This information could be harnessed to improve the efficiency and potency of new vaccines. Jim received numerous awards including the Keystone Symposia Future of Science Fund Scholarship and the University of Maryland's Michael J. Pelczar Award for Excellence in Graduate Study. Jim completed his PhD in the lab in 2017.
Neil graduated cum laude from Bucknell University in May 2012 with a B.S. in Biomedical Engineering. At Bucknell, Neil was an undergraduate researcher where he worked under the direction of Dr. Kathleen Bieryla to study clinical balance measures in older adults and also worked with mentors from the Geisinger Health System on pediatric medical device development. After graduation, he worked on the engineering team at BrainScope Company Inc., developing portable EEG devices to assess traumatic brain injury. Neil returned to school with a strong interest in biomaterials and is now looking to study their applications in immunology. Neil was an NIH NCI Fellow.
Next position: Systems Engineer, BrainScope.
Dr. Lisa H. Tostanoski, Ph.D. (January 2013 - December 2017)
Lisa was an NSF Graduate Fellow. Prior to joining the lab she received a B.S. in Biomedical Engineering from Bucknell University, graduating Magna Cum Laude and Tau Beta Pi honors. At Bucknell, Lisa was an undergraduate researcher in the biomechanics and injury prevention lab of Dr. Kathleen Bieryla. She gained additional research experience in tissue engineering, specifically orthopedic applications of regenerative medicine, through internships with the Union Memorial Hospital Orthobiologics Lab and at Bioactive Surgical, Inc. Lisa's PhD at the University of Maryland focused on directing immunological tolerance. She applied her work to therapeutic vaccines aimed at inducing immunological tolerance to treat autoimmune disorders such as multiple sclerosis more selectively. Dr. Tostanoski published more than a dozen papers and received numerous awards, including the prestigious Lemelson-MIT Prize, the American Chemical Society's Peterson Award, and the Department's Fischell Fellowship. Throughout her time, Lisa maintained a strong commitment to STEM outreach and mentoring. Dr. Tostanoski completed her time in the lab in December 2017.
Next position: Postdoctoral Fellow, Harvard University - Center for Vaccine Research (Advisor: Dan Barouch)
Lab Alumni: Undergraduate Researchers
Maryam Mukhamedova (Sept 2012 - May 2014)
Maryam Mukhamedova joined the lab in Sept 2012 and was a Howard Hughes Medical Institute Undergraduate Research Fellow. Prior to joining Dr. Jewell's lab, Maryam gained research experience working for Dr. Aleksander Jeremic in the Dept. of Biology at George Washington University. She investigated amylin fibrils in human mammalian cells to learn more about how amyloid fibrils formed in human diseases including Alzheimer's, Parkinson's disease, and Type II diabetes. Maryam work in the Jewell lab was based on delivery of self-antigens and regulatory immune signals to promote tolerance that could be harnessed to specifically control autoimmune reactions. During her free time, Maryam loves the outdoors, exploring new areas and is a big golf fan. Maryam graduated in 2014 and received a NIH Postbaccalaureate Intramural Research Training (IRTA) award to contact research in Dr. Reed Wickner's lab.
Next position: PhD candidate, Johns Hopkins University/NIH.
Eduardo Solano (Sept 2012 - Feb 2014)
Eddie Solano joined the lab in 2012 and was a Bioengineering and pre-med student. He graduated from Walter Johnson High School in 2010 after moving to the United States with his family from Colombia in 2007. Eddie was actively involved in research beginning freshmen year, participating in the Gemstone Honors Research program under the mentorship of Dr. John Fisher. His Gemstone research team studied the effects of electrical stimulation on the healing of diabetic foot ulcers. Eddie's work in the lab focused on design of a stereotactic injection device. Outside of school, Eddie enjoys reading, drawing/painting, and watching Spanish soap operas; he is also very fond of international cuisine, especially Chinese.
Next position: Training in cancer and medicine.
Elisabeth "Lily" Sooklal (Sept 2012 - Jan 2015)
Elisabeth “Lily” Sooklal joined the lab in 2012, pursuing a double major in Bioengineering and Spanish. She graduated from Franklin High School in 2012 and received a UMD Banneker Key Scholar. Lily's work in the lab focused on the design and composition of polyelectrolyte multilayer films in a collaboration with the University of Maryland medical school to design surface coatings that allow isolation and study of circulating breast tumor cells. When not studying or working in the lab, Lily enjoyed cooking, singing, traveling, and playing sports.
Next position: R&D Systems Engineer, Becton Dickinson (BD), Diagnostics Systems
Arjun Adapa (Jan 2013 - May 2016)
Arjun graduated with in May 2016 with a degree in Bioengineering. He was awarded a Fulbright Scholarship in the Netherlands for one year after graduation. Arjun was a Banneker/Key scholar and undergraduate student in the Fischell Department of Bioengineering. He received a Howard Hughes Medical Institute (HHMI) Fellowship in the spring of 2015 for his work in the lab, and was also previously selected as a prestigious UM Scholar at the University of Maryland Medical School's summer pre-med research program. Prior to joining Dr. Jewell’s lab, Arjun worked at the Johns Hopkins School of Medicine under the direction of Dr. Jonathan Powell in the Department of Oncology. He studied mechanisms governing immune cell activation and tolerance in the presence of cancer. His project in the lab focused on liposomal delivery of small molecule immune modulators to control inflammation during autoimmune disease. During his free time, Arjun plays the saxophone, and travels.
Next position: Medical school student, University of Michigan
Kevin Pineault (Jan 2014 - May 2016)
Kevin graduated from the University of Maryland with a degree in Bioengineering (Honors) in May 2016. He graduated from Concord High School in 2011 in Wilmington, Delaware. Kevin transferred to the University of Maryland in the Fall of 2013 and joined the Jewell Research Lab in the spring of 2014. Kevin is studied biomaterials used in vaccines and their impact on immune signaling pathways under the direction of Ph.D. candidate James Andorko. Kevin was an ASPIRE Fellow, received the Godo Biomedical Research Scholarship, the Maryland Summer Scholars Award, and the Outstanding ASPIRE Fellow of the year in 2015/2016. Outside the Lab, Kevin has an interest in improving engineering and pre-medical education, as well as hiking, backpacking, and volunteering at nearby medical centers and hospitals.
Next position: Medical school student, Johns Hopkins University
Anthony Trinh (Jan 2015 - May 2016)
Anthony (Tony) Trinh graduated in May 2016 with a B.S. in Biological Sciences and minor in nanoscale science and technology. Tony graduated from the International Baccalaureate Program at Richard Montgomery High School in 2012 and is currently a member of both the University Honors Program and the QUEST Honors Program. Prior to joining Dr. Jewell’s lab in Spring 2015, Tony had worked for a time at the National Institute of Neurological Disorders and Stroke in Bethesda, MD. Outside of the lab, Tony works as a Hospitalist Scribe at Suburban Hospital and as a Resident Assistant in Hagerstown Hall. He was also actively involved in both of his honors programs and a campus tutor with the Honors College for Chemistry, Biology and Business courses. In his free time, Tony is an avid sailor, swimmer, and fisher.
Next position: Medical school student, University of Maryland
Boyan Xia (Nov 2013 - May 2017)
Boyan graduated in May 2017 with a B.S. in Physiology & Neurobiology, and a minor in Statistics, during which she delivered the student commencement addressed. Boyan graduated from Thomas S. Wootton high school in 2013 and was part of the UMD honors college integrated life sciences program and a presidential scholar. Boyan joined the Jewell lab in the fall of 2013 and received a Howard Hughes Medical Institute (HHMI) Fellowship in the spring of 2015. Prior to joining the lab, she interned in the Laboratory of Molecular Pharmacology at the National Cancer Institute from 2012 to 2013. Boyan's project in the lab focused on controlled release of immune signals to induce immunological tolerance. In her free time, Boyan enjoys cooking, and reading.
Next position: Postbaccalaureate IRTA Fellow, NIH, NIAID Vaccine Research Center, Douek Lab
Jessica Yau (Jan 2015 - May 2018)
Jessica graduated with a B.S. in Bioengineering (Honors) in May 2018. She attended Winston Churchill High School before coming to UMD, enrolling on campus in fall 2014. Jessica was part of the Honors College Gemstone Program and joined the Jewell lab in the spring of 2015. Prior to joining the lab, she interned in the Laboratory of Protein Dynamics and Signaling at the National Cancer Institute from 2012 to 2014. As an undergraduate research in the Jewell Lab, Jessica studied controlled delivery of metabolic cues to promote immune tolerance. Ms. Yau was awarded a Howard Hughes Medical Institute (HHMI) Fellowship in the Spring of 2016, which supported her final two years of research in the lab. During her free time, Jessica travels, bakes, and plays the violin.
Next position: Postbaccalaureate IRTA Fellow, NIH, NCI, Berzofsky Lab