Damon Runyon-Rachleff Innovator Assistant Professor, Fischell Dept. of Bioengineering, University of Maryland, College Park Assistant Professor, Immunology and Microbiology, University of Maryland Medical School Full Member, Tumor Immunology, Marlene and Stewart Greenebaum Cancer Center Non-clinical Investigator, United States Dept. of Veterans Affairs, BLR&D Service
Christopher M. Jewell is an Assistant Professor in the Fischell Department of Bioengineering at the University of Maryland and a Damon Runyon-Rachleff Innovator. Dr. Jewell graduated from Lehigh University with high honors in 2003 with a B.S. in Chemical Engineering and a B.S. in Molecular Biology. He attended graduate school at the University of Wisconsin – Madison, completing his PhD in Chemical Engineering with Professor David Lynn in 2008. Chris then joined the Boston Consulting Group in New York City as a consultant in the Healthcare practice, where his work focused on R&D strategy development for global pharmaceutical and biotechnology clients. In 2009, Dr. Jewell accepted a postdoctoral fellowship from the Ragon Institute to begin vaccine research at MIT with Professor Darrell Irvine in the departments of Materials Science and Biological Engineering. Dr. Jewell held a concurrent appointment as a Visiting Scientist in the Division of Vaccine Research at Harvard. In August 2012, Chris established his lab at the University of Maryland. His research focuses on understanding the interactions between synthetic materials and lymph nodes, and exploiting these interactions for therapeutic vaccination.
Dr. Jewell has authored 32 peer-reviewed papers (H-index = 19) and 6 patent filings, including papers in ACS Nano, PNAS, Angewandte Chemie, and Nature. These efforts have been recognized by awards for research and education, including the NSF CAREER Award, the Damon Runyon-Rachleff Innovation Award, the Alliance for Cancer Gene Therapy Young Investigator Award, the Melanoma Research Alliance Young Investigator Award, the University of Maryland Research and Scholar Award, and the Fischell Department of Bioengineering's 2015 Teaching Excellence Award. Dr. Jewell has also led the lab's outreach efforts working with more than 400 area high school students to promote STEM research exposure, to contribute to the community education about STEM opportunities and cancer research, and with fundraising for local and national charities. Chris was previously the recipient of a Society for Biomaterials STAR Award, an American Association of Immunologists Trainee Award, and the Controlled Release Society T. Nagai Postdoctoral Achievement Award. In 2012, Dr. Jewell appeared in USA Today representing the Chemical Engineering discipline as a “New Face of Engineering” during National Engineers Week. Chris was also selected in 2013 as the state of Maryland’s Outstanding Young Engineer by the Maryland Academy of Science, the state’s highest professional honor awarded to an engineer under 36.
Dr. Xiangbin Zeng is the Lab Manager and technician for the Jewell Research Lab in the Fischell Department of Bioengineering at the University of Maryland. Dr. Zeng received his Bachelors degree in preventive medicine from Shanghai Medical University in China in 1997, and his Ph.D. in Toxicology from Fudan University in China in 2002. Dr. Zeng then conducted postdoctoral research at Tulane University before joining the Department of Radiation Oncology at Emory University Medical Center as a Research Association in 2006. Dr. Zeng’s cancer research at Emory focused on the role of centrosome amplification during tumorgenesis in human mammary glands. Xiangbin also served as a volunteer at the NIH for 1 year investigating the role of adaptive immune reactions during drug-induced liver injury in mice. Dr. Zeng’s past work has resulted in more than a dozen peer-reviewed publications in the fields of immunology and cancer. In addition to coordinating Jewell lab operations, his current position utilizes his expertise in molecular cell biology and immunology to help other lab members to push research projects forward. In his free time, Xiangbin is a big tennis fan and enjoys spending time with his two kids.
Dr. Qin Zeng is currently a postdoctoral scientist in the Jewell Research Lab in the Fischell Department of Bioengineering at the University of Maryland. Dr. Zeng received her B.S degree in Pharmacy from Hubei University of traditional medicine in 2009 and joined the Key Laboratory of Drug-Targeting and Drug Delivery System in Sichuan University. She completed a Master degree in 2012 and Ph.D degree in Pharmaceutics in 2015. Her master research focused on melanoma gene therapy using adenovirus complexed with a PEG derived polymer. During her doctoral studies, Qin constructed micelles-based cancer vaccines for melanoma immunotherapy. She has published three first author papers in top drug delivery journals such as the Journal of Controlled Release, and earned the National Scholarship for Outstanding Graduate Student. In the Jewell Lab, Dr. Zeng is continuing in the cancer immunotherapy field with an emphasis on controlling CD8+ T cell phenotype and deciphering the interactions or biomaterial-based cancer vaccines with the local lymph node microenvironment.
Dr. Peipei Zhang is currently a postdoctoral associate in the Jewell Research Lab. Dr. Zhang received his B.S. in Bioengineering in Northwest A & F University in China in 2006. He continued his graduate study in Chemical Engineering at South China University of Technology from 2006-2008. He completed his graduate training at the Florida State University, earning his Ph.D. in Biomedical/Chemical Engineering with Dr. Jingjiao Guan in 2013. After graduate school, Peipei worked as a postdoctoral researcher at Worcester Polytechnic Institute with Dr. Ming Su. Dr. Zhang’s research focused on micro/nanofabrication of particulate device for biomedical applications, e.g. drug delivery and cell tracking. Peipei’s work has resulted in 15 publications. His current research interests in the Jewell lab include using self-assembling materials to control immune polarization. His research also includes using microfluidic device to image cytoskeletal dynamics in free-floating tumor cells. Peipei enjoys reading and traveling, and likes to visit museums.
Jim is currently a American Association of Pharmaceutical Scientists (AAPS) Graduate Fellow, a University of Maryland Graduate Dean's Dissertation Fellow, and previously received an NIH doctoral fellowship. Prior to joining the University of Maryland, Jim completed a combined degree program at Drexel University in Philadelphia, graduating magna cum laude in 2012 with a Bachelor’s and Master’s in Biomedical Engineering. His master’s thesis focused on stealth drug delivery vehicles meant to avoid immune detection. During his time at Drexel, he worked in Dr. Margaret Wheatley’s Microencapsulation Laboratory at Drexel, and completed internships in Merck’s RNAi Therapeutics Division and at Synthes in the Biomaterials Division. Jim is currently interested in the study of biomaterials used in vaccines and how they impact immune signaling pathways. In particular, he is studying the relationship between physical and chemical properties of the biomaterial vaccine carriers and how the properties of these materials impact the lymph node environment. This information could be harnessed to improve the efficiency and potency of new vaccines. Jim has received several awards including the Keystone Symposia Future of Science Fund Scholarship and is a Clark Engineering School Future Faculty Fellow. Outside of research, Jim once competed in a semi-professional sport called Kronumis and was a part of the Pi Kappa Alpha Fraternity. He is also a passionate Philadelphia sports fan.
Michelle graduated from Brown University in 2013 with a B.S. in Chemical and Biochemical Engineering. She went on to receive her M.S. in Biomedical Engineering from Brown in 2014. While at Brown, Michelle worked under the direction of Dr. Anubhav Tripathi to study the bioremediation of oil spills utilizing hydrocarbon-degrading marine bacterium. Her work on this subject led to two first author publications. In the Jewell lab, Michelle plans to focus on using self-assembly of biomaterials for the development of cancer vaccines. In her free time, Michelle enjoys running and traveling.
Neil graduated cum laude from Bucknell University in May 2012 with a B.S. in Biomedical Engineering. At Bucknell, Neil was an undergraduate researcher where he worked under the direction of Dr. Kathleen Bieryla to study clinical balance measures in older adults and also worked with mentors from the Geisinger Health System on pediatric medical device development. After graduation, he worked on the engineering team at BrainScope Company Inc., developing portable EEG devices to assess traumatic brain injury. Neil returned to school with a strong interest in biomaterials and is now looking to study their applications in immunology. Outside of the lab, Neil is a saxophonist and has been playing in ensembles for over 15 years. Neil is also an ardent New England sports fan.
Joshua Gammon graduated in August 2012 with a B.S. in Bioengineering from the University of Maryland. As an undergraduate, Josh gained experience in medical device design as his capstone group achieved second place overall in the 2011-2012 UMD Bioengineering Capstone Design Competition. Josh is currently completing a Masters of Science in Bioengineering, working to develop a polymeric delivery system to help control neurodegeneration. He is continuing in his research as a PhRMA Foundation Doctoral Fellow and was previously the recipient of a Pediatric Oncology Student Training award from Alex's Lemonade Stand Foundation. Josh has also volunteered at Civista Medical Center in La Plata Maryland, assisting patients with physical therapy. In his free time he enjoys reading and spending time with his dog, Soto.
Emily Gosselin graduated from Tufts University in May 2015 with a B.S. in Biomedical Engineering. She is a member of the engineering honors society Tau Beta Pi, and graduated Magna Cum Laude. While at Tufts, Emily worked in Dr. David Kaplan’s Laboratory using silk fibroin as a biomaterial scaffold for cornea tissue engineering applications. For her work on this project, she earned the Tufts BME Senior Capstone of the Year Award and the Tufts Benjamin G. Brown Scholarship for research. In joining the Jewell Research Lab, she hopes to continue studying the use of biomaterials, but with a focus on using materials to regulate immune tolerance. Outside of research, Emily enjoys running, and ran her first half marathon in 2015. She is a strong supporter of Boston sports.
Krystina graduated from Syracuse University with a Bachelor’s in Bioengineering in May 2013. She was a member of the Renée Crown University Honors Program and graduated cum laude. Krystina worked at the Syracuse Biomaterials Institute as an undergraduate researcher beginning in her sophomore year. Under the direction of Dr. Rebecca Bader, she synthesized hyaluronate–coated polysaccharide nanoparticles for active targeting to inflamed tissue in rheumatoid arthritis. Krystina current projects in the Jewell lab focus on exploiting self-assembling materials to regulate immune function. She is currently a Department of Defense SMART Fellows and will launch a independent research career at Aberdeen Proving Ground after completing her PhD. Krystina has received several other awards, including the University of Maryland's Summer Research Fellowship. Krystina is a devoted Boston Red Sox and Buffalo Bills fan and also enjoys traveling.
Lisa Tostanoski graduated in May 2012 with a B.S. in Biomedical Engineering from Bucknell University with Magna Cum Laude and Tau Beta Pi honors. At Bucknell, Lisa was an undergraduate researcher in the biomechanics and injury prevention lab of Dr. Kathleen Bieryla. She gained additional research experience in tissue engineering, specifically orthopedic applications of regenerative medicine, through internships with the Union Memorial Hospital Orthobiologics Lab and at Bioactive Surgical, Inc. Lisa has developed a strong interest in the interactions between biomaterials and the immune system. Her current project interests include designing therapeutic vaccines to induce immunological tolerance to treat autoimmune disorders. She is currently an NSF Graduate Student Fellow and has received the Society for Biomaterials STAR Award and the Biomedical Engineering Society Graduate Student Design and Research Award. Outside of the lab, Lisa has been a competitive swimmer since the age of five and was a member of Bucknell’s Varsity Swimming and Diving Team. Lisa is also an extremely dedicated Baltimore Ravens fan.
Shannon Tsai graduated from the University of Pennsylvania in May 2012 with a B.S. in Materials Science. After graduation, Shannon worked in the lab of Dr. Andrew Rhim, performing clinical tests on microfluidic chips to screen for breast, ovarian, and pancreatic cancers. Shannon then joined the lab of Dr. Rebecca Wells, where she worked as a technician studying the role of mechanical factors on liver fibrosis and the mechanism behind biliary atresia. In Fall 2016 Shannon enrolled as a doctoral student at the University of Maryland to focus on the application of biomaterials and bioengineering to immunology. Outside of her research in the Jewell Lab, Shannon is a competitive ultimate Frisbee player for a Nationals qualifying team.
Lampouguin (Douti) graduated from the University of Maryland in 2015 with a B.S. in Bioengineering. He is a member of the engineering honors society Phi Theta Kappa and is currently a National Science Foundation Bridge-to-the-Doctorate Graduate Fellow. Lampouguin has also received a University of Maryland Fellowship to support his graduate studies. Lampouguin’s doctoral research is in the Malaria area, supervised by Dr. Carolina Barillas-Mury at the NIH Malaria Branch, and co-advised by Dr. Jewell. Lampouguin is also working to integrate biomaterials into improved malaria vaccines. Outside of research, Lampouguin enjoys playing soccer and tennis.
Boyan Xia is a Junior bioengineering major on a premed track at the University of Maryland. She graduated from Thomas S. Wootton high school in 2013. She is part of the UMD honors college integrated life sciences program and a presidential scholar. She joined Dr. Jewell's lab in the fall of 2013 and received a Howard Hughes Medical Institute (HHMI) Fellowship in the spring of 2015. Prior to joining the lab, she interned in the Laboratory of Molecular Pharmacology at the National Cancer Institute from 2012 to 2013. She is now working with doctoral candidate Lisa Tostanoski on designing therapeutic vaccines to induce immunological tolerance. In her free time, Boyan enjoys cooking, and reading.
Jessica Yau is a sophomore Chemical and Biomolecular Engineering major on the pre-medical studies track at the University of Maryland. She graduated from Winston Churchill High School in 2014. She is part of the UMD Honors College Gemstone Program and was an Intel Science Talent Search Semifinalist. Jessica joined Dr. Jewell’s lab in the spring of 2015 and has been selected as an ASPIRE Fellow. Prior to joining the lab, she interned in the Laboratory of Protein Dynamics and Signaling at the National Cancer Institute from 2012 to 2014. Jessica studied alternative pathways of mitophagy activation in the absence of the protein, Parkin. She is now working with postdoctoral associate Dr. Peipei Zhang and was been awarded a Howard Hughes Medical Institute (HHMI) Fellowship in the Spring of 2016. During her free time, Jessica travels, bakes, and plays the violin.
Lab Alumni: Postdoctoral Scientists
Dr. Yu-Chieh Chiu, Ph.D. (July 2013 - August 2016)
Dr. Yu-Chieh Chiu is currently a NIH Postdoctoral Fellow in the Jewell Research Lab. Dr. Chiu received his B.S. in Chemical Engineering from National Taiwan University of Science and Technology in 2003. He completed his graduate training at the Illinois Institute of Technology, earning an M.S. in Chemical Engineering with Dr. Victor Perez-Luna in 2007 and a Ph.D. in Biomedical Engineering with Dr. Eric Brey in 2011. After graduate school, Yu-Chieh accepted a postdoctoral position at Rice University with Dr. Antonios Mikos and was co-mentored by Dr. Cindy Farach-Carson in the department of Bioengineering. Dr. Chiu’s research focused on controlled delivery of growth factors from functionalized biodegradable scaffolds for bone and cartilage engineering. Yu-Chieh’s efforts have resulted in 15+ publications. His work in the lab focused on self assembly of immune signals to to study and improve the generation of CD8+ T cell response during cancer vaccination. Yu-Chieh completed work in the lab in 2016, accepting an exciting position as a scientist at the United States Food and Drug Administration (FDA).
Dr. Ashlee Tipton, Ph.D. (April 2014 - May 2015)
Dr. Ashlee Tipton joined the lab in 2014 as a postdoctoral research associate. Dr. Tipton received her B.S. in Biological Sciences from University of Maryland, College Park in 2008. She completed her graduate training at Georgia Regents University, earning a Ph.D in Biomedical Sciences with a major in Vascular Biology with Dr. Jennifer C. Sullivan in 2014. Dr. Tipton’s graduate work focused on elucidating the mechanism by which T cells contribute to hypertension in spontaneously hypertensive rats (SHR) and tested the hypothesis that there is a sex difference in the contribution of T cells to the maintenance of hypertension in SHR. Her research in the Jewell lab included engineering biomaterials for harnessing immune function during cardiovascular disease. She received an American Heart Association Fellowship for her proposal in this area (declined). Ashlee completed her time in the lab in 2015, accepting a fantastic position at the National Insitutes of Health as a program analyst at the National Center for Complementary and Integrative Health (NCCIH).
Lab Alumni: Graduate Students
Lab Alumni: Undergraduate Researchers
Maryam Mukhamedova (Sept 2012 - May 2014)
Maryam Mukhamedova joined the lab in Sept 2012 and was a Howard Hughes Medical Institute Undergraduate Research Fellow. Prior to joining Dr. Jewell's lab, Maryam gained research experience working for Dr. Aleksander Jeremic in the Dept. of Biology at George Washington University. She investigated amylin fibrils in human mammalian cells to learn more about how amyloid fibrils formed in human diseases including Alzheimer's, Parkinson's disease, and Type II diabetes. Maryam work in the Jewell lab was based on delivery of self-antigens and regulatory immune signals to promote tolerance that could be harnessed to specifically control autoimmune reactions. During her free time, Maryam loves the outdoors, exploring new areas and is a big golf fan. Maryam graduated in 2014 and received a NIH Postbaccalaureate Intramural Research Training (IRTA) award to contact research in Dr. Reed Wickner's lab. She was recently accepted into the prestigious joint NIH/Johns Hopkins GPP doctoral program.
Eduardo Solano (Sept 2012 - Feb 2014)
Eddie Solano joined the lab in 2012 and was a Bioengineering and pre-med student. He graduated from Walter Johnson High School in 2010 after moving to the United States with his family from Colombia in 2007. Eddie was actively involved in research beginning freshmen year, participating in the Gemstone Honors Research program under the mentorship of Dr. John Fisher. His Gemstone research team studied the effects of electrical stimulation on the healing of diabetic foot ulcers. Eddie's work in the lab focused on design of a stereotactic injection device. Outside of school, Eddie enjoys reading, drawing/painting, and watching Spanish soap operas; he is also very fond of international cuisine, especially Chinese. He graduated in 2014 and is currently pursuing career opportunities in medicine.
Elisabeth "Lily" Sooklal (Sept 2012 - Jan 2015)
Elisabeth “Lily” Sooklal joined the lab in 2012, pursuing a double major in Bioengineering and Spanish. She graduated from Franklin High School in 2012 and received a UMD Banneker Key Scholar. Lily's work in the lab focused on the design and composition of polyelectrolyte multilayer films in a collaboration with the University of Maryland medical school to design surface coatings that allow isolation and study of circulating breast tumor cells. When not studying or working in the lab, Lily enjoys cooking, singing, traveling, and playing sports.
Arjun Adapa (Jan 2013 - May 2016)
Arjun graduated with in May 2016 with a degree in Bioengineering. He was awarded a Fulbright Scholarship in the Netherlands for one year after graduation, and has been accepted to study Medicine at the University of Michigan afterwards. Arjun was a Banneker/Key scholar and undergraduate student in the Fischell Department of Bioengineering. He received a Howard Hughes Medical Institute (HHMI) Fellowship in the spring of 2015 for his work in the lab, and was also previously selected as a prestigious UM Scholar at the University of Maryland Medical School's summer pre-med research program. Prior to joining Dr. Jewell’s lab, Arjun worked at the Johns Hopkins School of Medicine under the direction of Dr. Jonathan Powell in the Department of Oncology. He studied mechanisms governing immune cell activation and tolerance in the presence of cancer. His project in the lab focused on liposomal delivery of small molecule immune modulators to control inflammation during autoimmune disease. During his free time, Arjun plays the saxophone, and travels.
Kevin Pineault (Jan 2014 - May 2016)
Kevin graduated with a degree in Bioengineering (Honors) in May 2016 and will study Medicine at Johns Hopkins University. He graduated from Concord High School in 2011 in Wilmington, Delaware. Kevin transferred to the University of Maryland in the Fall of 2013 and joined the Jewell Research Lab in the spring of 2014. Kevin is studied biomaterials used in vaccines and their impact on immune signaling pathways under the direction of Ph.D. candidate James Andorko. Kevin was an ASPIRE Fellow, received the Godo Biomedical Research Scholarship, the Maryland Summer Scholars Award, and the Outstanding ASPIRE Fellow of the year in 2015/2016. Outside the Lab, Kevin has an interest in improving engineering and pre-medical education, as well as hiking, backpacking, and volunteering at nearby medical centers and hospitals.
Anthony Trinh (Jan 2015 - May 2015)
Anthony (Tony) Trinh graduated in May 2016 with a B.S. in Biological Sciences and minor in nanoscale science and technology. He then enrolled in medical school at the University of Maryland - Baltimore Medical School. Tony graduated from the International Baccalaureate Program at Richard Montgomery High School in 2012 and is currently a member of both the University Honors Program and the QUEST Honors Program. Prior to joining Dr. Jewell’s lab in Spring 2015, Tony had worked for a time at the National Institute of Neurological Disorders and Stroke in Bethesda, MD. Outside of the lab, Tony works as a Hospitalist Scribe at Suburban Hospital and as a Resident Assistant in Hagerstown Hall. He was also actively involved in both of his honors programs and a campus tutor with the Honors College for Chemistry, Biology and Business courses. In his free time, Tony is an avid sailor, swimmer, and fisher.